SELI sea campaigns are set up since 2016 to inform on the biological effects of chemical contamination to marine organisms (fish and bivalve) and provide data for MSFD D8C2 assessment (contaminant effect in the marine ecosystem). SELI also generate data sent to regional sea conventions databases (OSPAR and MEDPOL). Monitored biomarkers include 1) effects on important biological functions: reprotoxicity, genotoxicity, neurotoxicity, as well as the 2) general health status of the organisms. Contaminants measured in the organisms are trace metallic elements and organic contaminants (historical and emerging) suspected to bioaccumulate in organisms and bioamplify in trophic webs. SELI is divided into 3 sub-protocols, one protocol being executed per year and therefore each protocol being executed every 3 years:

• - SELIMED: monitoring of the effects of the chemical contamination to red mullets (Mullus barbatus) and mussels (Mytilus galloprovincialis) in the Gulf of Lion (start: 2016).
• - SELILOIRE monitoring of the effects of the chemical contamination to sole (Solea solea) and mussels (Mytilus edulis) in the bays of Loire and Vilaine (start: 2017).
• - SELISEINE monitoring of the effects of the chemical contamination sole (Solea solea), flounder (Platichthys flesus) and mussels (Mytilus edulis) in the bays of Seine (start: 2018).

As such, SELI campaign is expected to assess:

- What are the levels of chemical contamination impregnation (historical and emerging) in marine organisms?

- What are the levels of the biological responses? Could they be associated to chemical contamination in area with

different anthropic pressures?